Review of Bacillus anthracis Dose Response Data for Human Health Risk Assessment
Citation:
Hines, S. Review of Bacillus anthracis Dose Response Data for Human Health Risk Assessment. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-16/147, 2016.
Impact/Purpose:
The report is designed to support the development of a site-specific human health risk assessment (HHRA) for Bacillus anthracis using available open source data and analysis approaches. The content reflects the output of an agent-specific planning activity for B. anthracis to identify and evaluate published dose-response data, identify data gaps and process gaps for microbial dose-response analysis of the agent, and identify science policy gaps that may need to be filled to conduct a site-specific HHRA for the agent.
Description:
Interest in low-dose dose-response relationships for Bacillus anthracis exposure can be traced to data gaps made apparent during the civilian response to the 2001 anthrax letter event. This report conducts a systematic review of Bacillus anthracis dose-response data that can be used to inform development of a dose-response relationship or to support the use of Bacillus anthracis dose-response data in a human health risk assessment.